Database : HANSEN Search on : MYCOBACTERIUM LEPRAE/METAB [Subject descriptor] References found : 56 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19529 Author: Adams, Linda B; Soileau, Nashone A; Battista, John R; Krahenbuhl, James L. Title: Inhibition of metabolism and growth of mycobacterium leprae by Gamma irradiation. Source: Int. J. Lepr;68(1):1-10, Mar., 2000. ilus, graf. Abstract: Mycobacterium leprae is uncultivable on artificial medium, but viability can be maintained without multiplication for a limited time in vitro. In this study, we evaluated gamma-irradiation (gamma-irr) as a means to kill this slowly growing organism. Freshly harvested, viable, athymic, nu/nu mouse-derived M. leprae were exposed to varying doses of gamma-irr from a 60Co source. Two indicators of bacterial viability were determined: metabolism, measured by oxidation of 14C-palmitic acid to 14CO2 in the BACTEC 460 system, and multiplication, measured by titration in the mouse foot pad. gamma-Irr of both M. leprae and M. lufu, a cultivable control mycobacterium, resulted in a dose-dependent inhibition of viability. gamma-Irr of up to 10(3) rad had little effect on the metabolic activity of either organism. For M. leprae, 10(4)-10(5) rad caused an intermediate inhibitory effect; whereas 10(6) rad yielded almost total inhibition. In the mouse foot pad assay, up to 10(4) rad had little effect on M. leprae growth; however, 10(5) rad resulted in at least a 2-log reduction in the number of bacilli recovered and no M. leprae growth was measurable after exposure to 10(6) rad. With M. lufu, 10(5) rad inhibited metabolic activity by 99% and caused > or = 2-log reduction in the number of colony forming units (CFU). No CFU of M. lufu were recovered after exposure to 10(6) rad. Scanning electron microscopy revealed the presence of some aberrant protrusions on the cell surface of lethally irradiated M. leprae; whereas boiling and autoclaving caused obvious morphological denaturation. These data suggest that gamma-irr is an effective way to kill M. leprae without causing extensive damage to the cell architecture. Killing M. leprae by gamma-irr may be preferable when comparing cellular responses to live versus dead bacilli in vitro and in vivo. (AU)^ien. Descriptors: Mycobacterium leprae/metab Mycobacterium leprae/fisiol Usos da Radiação Raios gama/uso terap Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n1/v68n1a01.pdf / en Location: BR191.1

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Id: 18576 Author: Cerqueira, Gil de Castro. Title: Eliminação do bacillo de Hansen pela via cutânea / Elimination of Hansen's Bacillo by cutis Source: Rev. Lepr. São Paulo;2(2):87-92, 1935. . Descriptors: Hanseníase/microbiol Hanseníase/fisiopatol Hanseníase/parasitol Hanseníase/virol Mycobacterium leprae/metab Mycobacterium leprae/fisiol Mycobacterium leprae/patogen Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1935/PDF/v2n2/v2n2a02.pdf / pt Location: Br191.1

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Id: 18520 Author: Rodrigues, J; Mabalay, E; Tolentino, J. C. Title: Formas Gram-positivas de M. leprae de lesões leproticas bacteriologicamente negativas para organismos acido-resistentes / Gram-positive forms of M. Leprae leprous lesions of bacteriologically negative for acid-resistant organisms Source: Rev. Lepr. São Paulo;1(2):111-121, Jan. 1934. ^btab. Abstract: 1) Pelo emprego do metodo de Much é possivel demonstrar a presença de formas gram-positivas de M. leprae numa percentagem consideravel de lesões leproticas que não contem bacilos acido resistentes. 2) Que muitos destes bacilos anacido-resistentes n„o s„o puramente formas degeneradas pode-se julgar do fato que s„o numerosas em muitos casos dos chamados fechados, incipientes que não sofreram tratamento (AU)^ipt. Descriptors: Mycobacterium leprae/citol Mycobacterium leprae/metab Mycobacterium leprae/fisiol Mycobacterium leprae/patogen Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1934/PDF/v1n2/v1n2a06.pdf / pt Location: BR191.1

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Id: 18470 Author: Lowe, John. Title: Repetição dos exames dos casos de lepra / Repetition of examinations of cases of leprosy with high Source: Rev. Lepr. São Paulo;1(1):28-30, Set. 1933. ^btab. Descriptors: Hanseníase/diag Hanseníase/microbiol Hanseníase/patol Hanseníase/fisiopatol Hanseníase/virol Mycobacterium leprae/cresc Mycobacterium leprae/isol Mycobacterium leprae/metab Mycobacterium leprae/patogen Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/leprolsp/1933/PDF/v1n1/v1n1a06.pdf / pt Location: BR191.1

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Id: 18462 Author: Truman, Richard; Fontes, Amanda B; Miranda, Antonio B. de; Suffys, Philip; Gillis, Thomas Title: Genotype variation and stability of four variable-number tandem repeats and their suitability for discriminating strains of Mycobacterium leprae^ien ..- Source: s.l; s.n; 2004. 8 p. ^btab. Abstract: It has not been possible to distinguish different strains of Mycobacterium leprae according to their genetic sequence. However, the genonme contais several variable-number tandem repeats (VNTR), which have been used effectively in strain typing of other bacteria. To determine their suitability for differentiating M. leprae, we developed PCR systems to amplify 5 different VNTR loci and examined a battery of 12 M. leprae strains derived from patients in different regions of the United States, Brazil, Mexico, and the Philippines, as well as from wild armadillos and sooty mangabey monkey. We found diversity at for VNTR (D = 0.74), butone system (C16G8) failed to yield reproducible results. Alleles for the GAA VNTR varied in length from 9 to 12 copies, andthose for AT17 varied in length from 13 to 20 copies. Relatively little variation was seen with interspecies transfer of bacilli or during short-term passage of strains in nude mice or armadillos. The TA18 locus was more polymorphic than other VNTR, and genotypic variation was more common after long-term expansion in armadillos. Most strain genotypes remained fairly stable in passage, but atrain Thai-53 showed reamrkable any particular genotype associable with different regions or hosts of origen. VNTR polymorphisms can be used effectively to discriminate M. leprae strains. Inclusion of additional loci and other elements will likely lead to robust typing system that can be used in community-based epidemiological studies and select clinical application (AU)^ien. Descriptors: Mycobacterium leprae/genet Mycobacterium leprae/imunol Mycobacterium leprae/metab Mycobacterium leprae/fisiol Mycobacterium leprae/patogen Hanseníase/imunol Hanseníase/virol Limits: Humanos Location: BR191.1; 09253/s

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Id: 18390 Author: Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K Title: Drug resistant-Mycobacterium leprae- results of mouse footpad studies from a laboratory in South India ..- Source: s.l; s.n; 2002. 12 p. tab. Abstract: Out of 265 biopsies of leprosy patients received at the Experimental Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae using the mouse footpad technique, 49 showed resistant strains of M. leprae to varying concentration of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resitance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistent strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emplasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community (AU). Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/ultraest RESISTÊNCIA A DROGAS DAPSONA/uso terap CLOFAZIMINA/uso terap RIFAMPINA/uso terap TESTES DE SENSIBILIDADE MICROBIANA/métodos TESTES DE SENSIBILIDADE MICROBIANA/vet - HANSENIASE/clas  HANSENIASE/compl  HANSENIASE/quimioter  HANSENIASE/imunol  HANSENIASE/microbiol  HANSENIASE/patol  OFLOXACINO/uso terap  MINOCICLINA/uso terap Limits: HUMANO Location: BR191.1; 09299/s

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Id: 18388 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordel, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. ilus, tab. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1x, CCL4/mip-1b, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatallites shows two peaks of linkage for leprosy at D17S250 (Z score 2.34; P=0.01) and D17S1795 (Z 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z 2.04; P=0.02). Combined analysis shows significant linkage genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic associationtesting that was robust to family clustering demonstrated siginificant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4Mb-CCL18-32.3kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2 (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 17/genet CROMOSSOMOS HUMANOS PAR 17/imunol PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol MYCOBACTERIUM TUBERCULOSIS/metab - HANSENIASE/genet  TUBERCULOSE/genet  BRASIL/etnol  BRASIL/epidemiol Limits: HUMANO ANIMAL Location: BR191.1; 09314/s

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Id: 18387 Author: Miller, E. N; Jamieson, S. E; Jobert, C; Fakiola, M; Peacock, C. S; Cordell, H. J; Shaw, M. A; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1,405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. A stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers types in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.78, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10-5; D17S1868.2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS HANSENIASE/genet TUBERCULOSE/genet - MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM TUBERCULOSIS/imunol  MYCOBACTERIUM TUBERCULOSIS/metab Location: BR191.1; 09313/s

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Id: 18385 Author: Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong Title: Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice ..- Source: s.l; s.n; 2000. 3 p. tab. Abstract: Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP. Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slighthy more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae (AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/farmacol HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE TESTES DE SENSIBILIDADE MICROBIANA/métodos DROGAS EM INVESTIGACAO/admin DROGAS EM INVESTIGACAO/anal DROGAS EM INVESTIGACAO/uso terap - BACTERICIDAS  QUIMIOTERAPIA COMBINADA  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM LEPRAE/fisiol  DAPSONA/uso terap  RIFAMPINA/uso terap  CLOFAZIMINA/uso terap  OFLOXACINO/uso terap  MINOCICLINA/uso terap  CLARITROMICINA/uso terap Limits: ESTUDO COMPARATIVO Location: BR191.1; 09311/s

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Id: 18349 Author: Delville, J Title: Acid-fast and non-acid-fast forms of the leprosy bacillus: implications in the diagnosis of leprosy ?- Source: s.l; s.n; 1979. 3p p. . Descriptors: MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/ultraest - HANSENIASE/etiol  HANSENIASE/imunol  HANSENIASE/microbiol Limits: IN VITRO Location: BR191.1; 00361/s

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Id: 18308 Author: Mansfield, R. E Title: Histopathology of leprosy ..- Source: s.l; s.n; s.d. 7 p. ilus. Descriptors: HANSENIASE/microbiol HANSENIASE/fisiopatol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen Limits: ESTUDO COMPARATIVO Location: BR191.1; 01093/d.a

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Id: 18265 Author: Antia, Noshir H Title: Persistence of Mycobacterium leprae in the peripheral nerve ..- Source: s.l; s.n; 1983. 422 p. tab. Descriptors: NERVOS PERIFERICOS/microbiol NERVOS PERIFERICOS/fisiol NERVOS PERIFERICOS/virol MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen MYCOBACTERIUM LEPRAE/virol HANSENIASE/imunol Limits: RELATO DE CASO Location: Br191.1; 01942/S

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Id: 18161 Author: Cannon, Willard E Title: Social casework for patients with hansens disease ..- Source: s.l; s.n; 1964. 7 p. . Descriptors: HANSENIASE/clas HANSENIASE/hist HANSENIASE/fisiopatol HANSENIASE/transm MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO Location: BR191.1; 01869/s

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Id: 17893 Author: Helene, Lúcia Maria Frazäo; Leäo, Viviane Murilla; Minakawa, Márcia Michie. Title: Perfis epidemiológicos e a avaliaçäo de incapacidades físicas de hansenianos de uma UBS de Säo Paulo / The social situation and the presents of physical disabilites among leprosy patients registered at a Public Health Center in Säo Paulo City Source: Hansen. int;26(1):5-13, jan.-jun. 2001. tab. Abstract: A finalidade deste estudo foi a de construir uma rede de conhecimento acerca de incapacidades físicas dos doentes com hanseníase em registro ativo em um Centro de Saúde de Säo Paulo. Os objetivos foram: determinar o grau de incapacidade física e identificar o modo particular de manifestaçäo social das famílias dos doentes estudados. A amostra foi constituida por 24 doentes com hanseníase que compareceram ao Centro de Saúde no período da coleta de dados, que ocorreu após o consentimento esclarecido dos doentes concordando em participarem deste estudo. Os dados foram analisados no software EPI INFO 6. Os resultados mostram, como maior freguência, que os doentes tinham 45 a 60 anos de idade e primeiro grau de escolaridade; 58(por cento) eram trabalhadores, assalariados 78(por cento), nos Serviços Gerais 64(por cento), desenvolvendo atividades näo qualificadas 71(por cento); 38(por cento) consideravam-se expostos a riscos como acidente de trânsito e drogas. Dos doentes, 79(por cento) eram multibacilares e 87(por cento) apresentavam incapacidades físicas, sendo que 46(por cento) com grau 2, seguidos de 37(por cento) com grau 1...(AU) . Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev MYCOBACTERIUM LEPRAE/metab Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1

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Id: 17022 Author: Feldman, William H; Moses, Harold E. Title: The effect of diphtheria toxoid on experimental tuberculosis. Source: Int. J. Lepr;11(n.esp):36-42, Dec. 1943. tab. Abstract: Using guinea-pigs infected experimentally with human tubercle bacilli and rabbits infected experimentally with bovine tubercle bacilli, a series of studies was made to ascertain whether or not diphtheria toxoid would influence the expected course of the resultant tuberculosis. Seventhy guinea-pigs and ten rabbits were used. The administration of toxoid in relation to the inoculation of the animals with the infective agent varied in the different studies. In two groups of guinea-pigs, treatment was started the same day that the animals were infected. In another group treatment was delayed for four weeks after the animals had been infected, and in another group the guinea-pigs had received two doses of toxoid one month apart before being infected. The rabbits received the first dose of toxoid simultaneously with the infective organism. The initial dose of toxoid for the guinea-pigs was 0.1 cc. Subsequent doses were administered every two weeks, with each succeeding dose 0.05cc. greater than the preceding dose. The initial dose for rabbits was 0.2cc. This was increased by 0.1cc. at each succeeding injection, whch was at two week intervals. The toxoid was injected intramuscularly. The experiments continued until all of the animals had died, which was somewhat in excess of seven months. All of the animals died of tuberculosis, and there were no significant differences between the treated and the untreated froups. The results indicate quite convincingly that under the conditions of the experiments diphtheria toxoid failed to exert any significant deterrent effect on tuberculosis experimentally induced in guine´-pigs and in rabbits. (AU). Descriptors: TUBERCULOSE MYCOBACTERIUM TUBERCULOSIS/ef drogas MYCOBACTERIUM TUBERCULOSIS/isol MYCOBACTERIUM TUBERCULOSIS/patogen TOXOIDE DIFTERICO/farmacol TOXOIDE DIFTERICO/uso terap - MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM LEPRAE/patogen Limits: ANIMAL Location: BR191.1

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Id: 15222 Author: Denney, O. E; Eddy, Bernice E. Title: Leprosy; comments on in vitro behavior of lepra and certain other acid-fast micro-organisms in presence of leukocytes. Source: Int. J. Lepr;1(4):476-482, Oct. 1933. ilus. Abstract: Acid-fast bacilli in Tyrode´s solution have been subjected to rabbits´leukocytes from peptone pleural effusions. Bacilli of the tuberculosis group proliferated readily in the presence of both living and subsequently dead leukocytes. Phagocytosed bacilli proliferated until the death of the phagocyte. Both intra and extracellular colonization produced irregular stellate clumps. Bacilli of the nonpathogenic group proliferated readily, but were not greedily phagocytosed. Colonization was predominantly extracellular, and the colonies were irregular and often stellate. Of the bacilli cultivated by others from lepers, eleven strains were distinctly attracted to the leukocytes; fourteen were not. With the former, intracellular proliferation continued until eventually the phagocyte was ruptured. The latter grew principally extracellularly, and when phagocytosed appeared not to proliferate rapidly, if at all. Rat leprosy bacilli were readily phagocytosed, as single rods and small clumps. Within the cell proliferation continued until the phagocyte was distended to the point of rupture, the intracellular growth sometimes being dense and distinctly globular. Extracellular colonies progressively increased in size and some of the dense, spherical masses were indistinguishable from globi. Leprosy bacilli and globi obtained from an incision in a nodule showed chemotactic affinity with the rabbits´ leukocytes, but no proliferation of the single rods or increase in the size of the globi. Pus from leprous abscesses also underwent phagocytosis. There was no definite increase of free bacilli, but a definite increase in the number and size of globi. Subsequent additions of fresh leukocytes appeared to cause a progressive increase in the size of the globi, and the formation of additional small ones; this formation of new globi apparently ceased when free organisms were no longer present in the suspension. (AU). Descriptors: MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/metab Location: BR191.1

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Id: 15180 Author: Hoffmann, W. H. Title: The granular forms of the leprosy bacillus. Source: Int. J. Lepr;1(2):149-158, Apr. 1933. ilus. Abstract: The leprosy bacillus, like other acid-fast bacilli, produces in its evolutionary cycle great numbers of granular forms which are found both within the bacilli and as free-lying bodies. These granules constitute an essential phase in its evolution. Among the free-lying forms are those of all sizes down to the limits of visibility, so that it is probable that still smaller, perhaps invisible and filterable forms exist, which may be of special though as yet unknown importance in the pathology and epidemiology of the disease. The supposition is feasible that many of these granular forms are phenomena of degeneration and disintegration, which are determined in part by the defensive substances of the organism and in part by the action of our medicinal products, and especially by the chaulmoogra oil; therefore, their presence can be considered a favorable sign. Howevwe, a careful study of the granular forms suggests that they should not be considered solely as degenerative forms. Evidence is given that in other cases they seem to be especially resistant or young forms, essential for the preservation and perhaps propagation of the microorganism of leprosy. Obviously, the importance of these forms for scientific study and practical work in leprosy cannot be overestimated...(AU). Descriptors: HANSENIASE HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/transm MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM LEPRAE/patogen Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 14893 Author: Miranda, Ruy N. Title: Fagocitose e destruição de Mycobacterium leprae por leucocitos polimorfonucleres. Source: Fontilles - Revista de Leprología;9(1):33-35, Ene.-Abr. 1973. . Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE/clas MYCOBACTERIUM LEPRAE/metab Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 13864 Author: Maestre Mesa, Jorge Luis; González Segredo, Ángel. Title: Ensayo de la prueba cutánea con el antígeno soluble del Mycobacterium leprae en un grupo de riesco. Source: Fontilles - Revista de Leprología;18(1):55-62, Ene.-Abr. 1991. tab, graf. Abstract: Se realizó un estudio mediante pruebas cutáneas con antígeno soluble de M. leprae (ASMI y derivado purificado de porteínas (PPD) en 192 convivientes de pacientes de lepra multibacilar, con el objetivo de evaluar la utilidad del método para identificación de indivíduos presumiblemente infectados com M. leprae. Todos ellos residían en el municipio Guantánamo, que es el área de más alta prevalencia de lepra en Cuba. El tamaño medio de la reacción fue 5'03 mm. mientras que en los grupos de control utilizado fue 0 mm. en pacientes lepromatosos, 18'62 mm. en pacientes tuberculoide, 2'75 mm. en pacientes tuberculosis pulmonar y 1'72 en individuos sanos. El criterio de positividad para ambas pruebas fue de 6 mm. Se observó que la prueba cutánea con ASMI puede der útil para al conducción de estudios epidemiológicos ya que, entre los convivientes positivos, el tamaño de la reacción fue significativamente mayor que el observado con el PPD. (AU). Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab ANTIGENOS/imunol Location: BR191.1

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Id: 13550 Author: Khanolkar, Saroj R; Ambrose, E. J; Mahadevan, P. R Title: Uptake of 3, 4-dihydroxy(3H)phenylalanine by Mycobacterium leprae isolated from frozen (-80 degrees C) armadillo tissue ..- Source: s.l; s.n; dec. 1981. 5 p. tab, graf. Abstract: Mycobacterium leprae separated from armadillo tissues stored at -80 degrees C is similar to that from human sources in its ability to take up 3H-labelled 3,4-dihydroxyphenylalanine (DOPA). Several inhibitors were studied which showed complete or partial inhibition of [3H]DOPA uptake. These findings suggest that M. leprae isolated from frozen tissue possesses an active uptake system for [3H]DOPA.(AU). Descriptors: TATUS/microbiol ACIDO ASCORBICO/farmacol QUELANTES/farmacol DIIDROXIFENILALANINA/metab MYCOBACTERIUM LEPRAE/metab BACO/microbiol TEMPERATURA AMBIENTE XENARTROS/microbiol Limits: ANIMAL SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00902/s

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